NVP-BQS481 [CAS 1161925-41-2]

NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC50IC50: 0.0.9 nM for SK-OV-3ip cells) . NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) [1].

[1161925-41-2]

C27H33F3N4O2

502.57

FC[C@@H](N)CCN(C(CO)=O)[C@H](C(C)(C)C)C1=NC(C2=C(F)C=CC(F)=C2)=CN1CC3=CC=CC=C3

ADC Payload; Kinesin

Kinesin-5/Eg5/KSP

Room temperature