NX-2127 [CAS 2416131-46-7]

NX-2127 (Compound 28) is an orally active PROTAC deggrader, targeting to Bruton’s Tyrosine Kinase (Btk). NX-2127 inhibits proliferation of BTKC481S mutant TMD8 cells, more effectively than Ibrutinib. NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells[1][2]. (Pink: BTK ligand 10 (HY-168302) ; Black: (R) -4- (1- (Pyrrolidin-3-ylmethyl) piperidin-4-yl) aniline (HY-168348) ; Blue: Thalidomide 5-fluoride (HY-W087383)

[2416131-46-7]

C39H45N9O5

719.83

O=C1C2=CC(N3C[C@H](CN4CCC(C5=CC=C(C=C5)NC6=C(N=CC(N7CCCCC7)=N6)C(N)=O)CC4)CC3)=CC=C2C(N1C8C(NC(CC8)=O)=O)=O

Btk; PROTACs

99.72

DMSO : 100 mg/mL (ultrasonic)

4°C (Powder, protect from light)

Room Temperature