NZ-66 [CAS 3062992-25-7]

NZ-66 is a UNC-51-like kinase 1 (ULK1) targeting chimera, which is used to achieve proximity-induced and ULK1-dependent degradation of mitochondria. NZ-66 induces mitophagy. NZ-66 is potential for attenuating neurodegenerative disorders[1].

[3062992-25-7]

C48H40F8N8O5

960.87

O=C(NC1=CC=C(F)C=C1F)[C@H](NC(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)C3=CC=C(OCC4=CN(CCCCCCNC(C(C5=C(C6=CC=CC=C6)NC7=C5C=CC=C7)=O)=O)N=N4)C=C3

Mitophagy; ULK

ULK1

Room temperature