O-Desmethyl carvedilol-d5 [CAS 1794817-24-5]
O-Desmethyl carvedilol-d5 [CAS 1794817-24-5]
SKU:QM-0008294-01
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Product Details
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Description
O-Desmethyl carvedilol-d5 (Desmethylcarvedilol-d5) is deuterium labeled O-Desmethylcarvedilol. O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol. O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2R4496C) mutation (IC50 = 7.62 μM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED50s = 32 and 5 μg/kg, respectively)[2].
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CAS Number
[1794817-24-5]
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Molecular Formula
C23H19D5N2O4
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Molecular Weight
397.48
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Smiles
OC(C=CC=C1)=C1OCCNC([2H])([2H])C(O)([2H])C([2H])([2H])OC2=C3C4=CC=CC=C4NC3=CC=C2
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Target
Calcium Channel; Isotope-Labeled Compounds
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Shipping Conditions
Room temperature
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O-Desmethyl carvedilol-d5 [CAS 1794817-24-5]
O-Desmethyl carvedilol-d5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.