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O-Desmethyl gefitinib [CAS 847949-49-9]
O-Desmethyl gefitinib [CAS 847949-49-9]
SKU:QM-0079068-01
£238.32 GBP
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Product Details
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Description
O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].
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CAS Number
[847949-49-9]
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Molecular Formula
C21H22ClFN4O3
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Molecular Weight
432.88
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Smiles
OC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4CCOCC4
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Target
EGFR
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Concentration
10mM
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Purity
99.4
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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O-Desmethyl gefitinib [CAS 847949-49-9]
O-Desmethyl gefitinib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.