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O-Desmethyl gefitinib-d6
O-Desmethyl gefitinib-d6
SKU:QM-0079070-01
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Product Details
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Description
O-Desmethyl gefitinib-d6 is the deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].
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Molecular Formula
C21H16D6ClFN4O3
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Molecular Weight
438.91
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Smiles
OC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OC([2H])([2H])C([2H])([2H])C([2H])([2H])N4CCOCC4
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Target
EGFR; Isotope-Labeled Compounds
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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O-Desmethyl gefitinib-d6
O-Desmethyl gefitinib-d6 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.