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O-Desmethyl gefitinib-d8
O-Desmethyl gefitinib-d8
SKU:QM-0079069-01
£652.64 GBP
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Product Details
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Description
O-Desmethyl gefitinib-d8 is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].
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Molecular Formula
C21H14D8ClFN4O3
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Molecular Weight
440.93
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Smiles
OC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4C([2H])([2H])C([2H])([2H])OC([2H])([2H])C4([2H])[2H]
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Target
EGFR
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Purity
99.84
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Solubility
10 mM in DMSO|DMSO : 100mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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O-Desmethyl gefitinib-d8
O-Desmethyl gefitinib-d8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.