OATD-02 [CAS 2146132-73-0]

OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study[1].

[2146132-73-0]

C12H25BN2O4

272.15

N[C@]1(C(O)=O)C[C@H](CCB(O)O)CC[C@H]1CN(C)C

Arginase

10 mM in DMSO

Room temperature