ODE-Bn-PMEG [CAS 1626364-18-8]

ODE-Bn-PMEG is an antiviral compound with strong inhibitory activity against HPV-11, -16, and -18. ODE-Bn-PMEG effectively reduced transient amplification of viral DNA in transfected cells at concentrations well below its cytotoxic levels. ODE-Bn-PMEG showed increased uptake in human foreskin fibroblasts and was able to be efficiently converted to the active antiviral metabolite PMEG diphosphate in vitro. The P-chiral enantiomer of ODE-Bn-PMEG showed comparable antiviral activity, indicating its potential application against multiple HPV types. ODE-Bn-PMEG is a promising candidate for local inhibition of HPV-16, HPV-18, and other high-risk types[1].

[1626364-18-8]

C35H58N5O6P

675.84

O=C1N=C(NC2=C1N=CN2CCOCP(OCC3=CC=CC=C3)(OCCOCCCCCCCCCCCCCCCCCC)=O)N

Endogenous Metabolite

Room temperature