OM99-2 [CAS 314266-76-7]

OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor[2]. OM99-2 has the potential for the research of the Alzheimer's disease[3].

[314266-76-7]

C41H64N8O14

892.99

OC([C@H](CC1=CC=CC=C1)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](C)C[C@H](O)[C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@@H](N)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O

Beta-secretase

BACE1

10 mM in DMSO

Room temperature