ONC213 [CAS 1977540-13-8]

ONC213 is an orally active αKGDH inhibitor. ONC213 can suppress mitochondrial respiration and elevate α-ketoglutarate levels by inhibiting αKGDH activity. ONC213 can induce cells apoptosis by inducing mitochondrial stress response and inhibiting translation of MCL-1. ONC213 can be used for the research of cancer, such as acute myeloid leukemia research (AML) [1].

[1977540-13-8]

C23H22F2N4O

408.44

O=C1N(CC2=CC=C(F)C(F)=C2)C3=NCCN3C4=C1CN(CC4)CC5=CC=CC=C5

Apoptosis; Caspase; Mitochondrial Metabolism; PARP

Caspase 3

99.89

DMSO : 100 mg/mL (ultrasonic)

4°C (Powder, stored under nitrogen)

Room Temperature