Orazipone [CAS 137109-78-5]

Orazipone (OR 1384) is a small molecule immunomodulator with strong anti-inflammatory properties. Orazipone exerts its immunomodulatory effect by forming reversible thiol complexes, which bind to intracellular signaling proteins and the thiol groups of glutathione. Orazipone exhibits potent anti-eosinophilic activity by inducing apoptosis. Orazipone inhibits activation of inflammatory transcription factors NF-kB and STAT 1 and decreases inducible iNOS expression and NO production in response to inflammatory stimuli. Orazipone reduces NADPH oxidase activity and thereby decreases ROS production. Orazipone has a protective effect in intestinal radiation injury[1][2][3].

[137109-78-5]

C13H14O4S

266.31

O=C(C)/C(C(C)=O)=C\C1=CC=C(S(=O)(C)=O)C=C1

Apoptosis; NADPH Oxidase; NF-κB; NO Synthase; Reactive Oxygen Species (ROS) ; STAT

INOS; NF-κB; STAT1

Room temperature