Org 274178-0

Org 274178-0 is a selective thyroid-stimulating hormone receptor (TSHR) antagonist with a pIC50 value for TSHR is 5.03. Org 274178-0 inhibits the activation of cAMP signaling pathway and phospholipase C (PLC) signaling pathway mediated by thyroid-stimulating hormone (TSH) and TSH receptor-stimulating immunoglobulins (TSIs) . Org 274178-0 is promising for research of Graves’ disease and Graves’ ophthalmopathy[1].

C28H27F3N2O2

480.52

C[C@@]1(C2=CC=CC=C2)C3=CC(NC(CCC4=CC(C(F)(F)F)=CC=C4)=O)=CC=C3N(CC1)C(C)=O

TSH Receptor

99.4

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature