Orphenadrine [CAS 83-98-7]
Orphenadrine [CAS 83-98-7]
SKU:QM-0152426-01
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Product Details
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Description
Orphenadrine ((±) -Orphenadrine) is a skeletal muscle relaxant and NMDA antagonist that also has antiparkinsonian, antihistamine, antitremor, antispasmodic, and analgesic effects. Orphenadrine inhibits the binding of [3H]MK-801 to the phencyclidine (PCP) binding site of the NMDA receptor. Orphenadrine is also an anticholinergic and CYP2B inducer. Orphenadrine may exert pro-tumor effects, causing CAR nuclear translocation, resulting in microsomal reactive oxygen species (ROS) production and oxidative stress. Orphenadrine also exerts neuronal protection, protecting rat cerebellar granule cells (CGC) from 3-NPA-induced death and has inhibitory potential against neurodegenerative diseases mediated by NMDA receptor overactivation[1][2][3].
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CAS Number
[83-98-7]
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Molecular Formula
C18H23NO
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Molecular Weight
269.38
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Smiles
CN(C)CCOC(C1=C(C)C=CC=C1)C2=CC=CC=C2
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Target
Cholinesterase (ChE) ; Cytochrome P450; iGluR
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Purity
99.71
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Orphenadrine [CAS 83-98-7]
Orphenadrine is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.