OSI-7904L [CAS 139987-54-5]

OSI-7904L (GW1843) is a noncompetitive inhibitor of thymidylate synthase (TS) . OSI-7904L is an antifolate compound and a substrate for folylpolyglutamate synthetase. OSI-7904L has cytotoxicity against solid tumor lines, and the toxicity can be selectively blocked by folic acid[1].

[139987-54-5]

C27H24N4O6

500.5

O=C1C2=C3C(C=CC(CNC4=CC=C(C(N(C5)[C@H](C(O)=O)CCC(O)=O)=O)C5=C4)=C3)=CC=C2NC(C)=N1

Antifolate; Thymidylate Synthase

Room temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501