Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM) ; Osoresnontrine can be used in the research of memory enhancement in CNS disorders.
CAS Number
[1189767-28-9]
Molecular Formula
C16H17N5O2
Molecular Weight
311.34
Smiles
O=C1C2=C(N(C3CCOCC3)N=C2)NC(CC4=CC=CC=N4)=N1
Target
Phosphodiesterase (PDE)
Isoform
PDE1; PDE9
Concentration
10mM
Purity
99.88
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)