Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor[1]. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene potently inhibits Caspase-1 and is used for the autoimmune diseases and certain malignancies[2][3][4].
CAS Number
[106566-58-9]
Molecular Formula
C2H8Cl3NO2Te
Molecular Weight
312.05
Smiles
[Cl-][Te+4]1([Cl-])([Cl-])[O-]CC[O-]1.[NH4+]
Target
Caspase; Interleukin Related
Isoform
Caspase 1; IL-1; IL-10; IL-6; IL-8
Purity
98
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)