P-fin4 [CAS 2883747-74-6]

P-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators[1].

[2883747-74-6]

C39H53N8O18P

952.85

N[C@@](CCC(O)=O)(C(NCC(N[C@@](Cc1ccc(O)cc1)(C(N[C@@](CC(N)=O)(C(N[C@@](C(C)C)(C(N[C@H](C(N[C@@](CCC(O)=O)(C(O)=O)[H])=O)CC2=CC=C(C=C2)OP(O)(O)=O)=O)[H])=O)[H])=O)[H])=O)=O)[H]

IGluR

AMPA Receptor

10 mM in DMSO

Room temperature