P3Ysh-3

P3Ysh-3 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 1.09 μM. p3Ysh-3 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p3Ysh-3 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators[1].

C41H60N9O18P

997.94

NCCOCCOCCNC(N[C@@](CCC(O)=O)(C(NCC(N[C@@](Cc1ccc(O)cc1)(C(N[C@@](CC(N)=O)(C(N[C@@](C(C)C)(C(N[C@H](C(O)=O)CC2=CC=C(C=C2)OP(O)(O)=O)=O)[H])=O)[H])=O)[H])=O)=O)[H])=O

IGluR

AMPA Receptor

10 mM in DMSO

Room temperature