Paclitaxel-bromothiophene
Paclitaxel-bromothiophene
SKU:QM-0013517
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Product Details
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Description
Paclitaxel-bromothiophene is a semisynthetic taxane analogue of Paclitaxel. Paclitaxel-bromothiophene exhibits potent antiproliferative activity against 4-T1 breast cancer cells, with an IC50 value of 15.18 nM. Paclitaxel-bromothiophene shows high binding affinity to C5aR1 (Kd = 19.4 μM). Paclitaxel-bromothiophene demonstrates excellent anti-tumor efficacy in 4-T1 breast cancer-bearing mice. Paclitaxel-bromothiophene can be used for the study of breast cancer[1].
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Molecular Formula
C45H48BrNO14S
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Molecular Weight
938.83
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Smiles
O=C1[C@H](OC(C)=O)C(C2(C)C)=C(C)[C@@H](OC([C@H](O)[C@@H](NC(C3=CC=CC=C3)=O)C4=CC=C(Br)S4)=O)C[C@@]2(O)[C@@H](OC(C5=CC=CC=C5)=O)C6[C@@]1(C)[C@@H](O)C[C@@]7([H])OC[C@]76OC(C)=O
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Target
Drug Derivative
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Shipping Conditions
Room temperature
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Paclitaxel-bromothiophene
Paclitaxel-bromothiophene is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.