PAIR2 [CAS 2771006-54-1]

PAIR2 is a potent and selective partial antagonist of IRE1α RNase. PAIR2 can completely occupy IRE1α’s ATP-binding site in cells and block the ability of a potent KIRA to inhibit XBP1 splicing[1].

[2771006-54-1]

C27H26F4N6O3S

590.59

CC(C(F)=C(NS(CC(F)(F)F)(=O)=O)C1=C2C=CC=C1)=C2OC3=NC=CC=C3C4=NC(N[C@H]5CCCNC5)=NC=C4

IRE1

10 mM in DMSO

Room temperature