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Palbociclib (orotate) [CAS 2757498-64-7]
Palbociclib (orotate) [CAS 2757498-64-7]
SKU:QM-0074388
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Product Details
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Description
Palbociclib (PD 0332991) orotate is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib orotate has potent anti-proliferative activity and induces cell cycle arrest in cancer cells. Palbociclib orotate can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4].
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CAS Number
[2757498-64-7]
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Molecular Formula
C29H33N9O6
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Molecular Weight
603.63
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Smiles
O=C1C(C(C)=O)=C(C2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCNCC5)C=N4)C.O=C6C=C(C(O)=O)NC(N6)=O
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Target
CDK
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Isoform
CDK4; CDK6
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Palbociclib (orotate) [CAS 2757498-64-7]
Palbociclib (orotate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.