Palbociclib-propargyl [CAS 2366269-23-8]
Palbociclib-propargyl [CAS 2366269-23-8]
SKU:QM-0143158-01
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Product Details
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Description
Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1]. Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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CAS Number
[2366269-23-8]
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Molecular Formula
C27H31N7O2
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Molecular Weight
485.58
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Smiles
O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCN(CC#C)CC4)C=C3)N=C2N1C5CCCC5
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Target
Ligands for Target Protein for PROTAC
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Purity
96.12
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Solubility
DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C (Powder, stored under nitrogen)
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Shipping Conditions
Blue Ice
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Palbociclib-propargyl [CAS 2366269-23-8]
Palbociclib-propargyl is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.