Pan-KRAS-IN-7

Pan-KRAS-IN-7 (Compound 25) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC50 of 0.35 and 0.51 nM, respectively[1].

C48H61N7O7S

880.11

OC[C@@H]1N(CC#CC2=C[C@]([C@]3=C(CC(C)(C)COC4=O)C5=CC(C6=CSC(C[C@H](NC([C@H]7[C@H](C)[C@@H]7C)=O)C(N8CCC[C@@H]4N8)=O)=N6)=CC=C5N3CC)=C([C@H](C)OC)N=C2)CCOC1

Ras

10 mM in DMSO

Room temperature