PBP4-IN-1

PBP4-IN-1 (Compound 1) is an inhibitor of penicillin-binding protein 4 (PBP4) of Staphylococcus aureus. PBP4-IN-1 enhances the inhibitory activity of antibiotics against PBP2a-mediated methicillin-resistant Staphylococcus aureus (MRSA) by inhibiting the function of PBP4. PBP4-IN-1 can be used for the study of osteomyelitis caused by Staphylococcus aureus and for the study of reversing PBP4-mediated resistance to β-lactam antibiotics.

C20H22ClN3O2

371.86

CC1CCN(C(C2=CC(NC(NC3=CC=C(Cl)C=C3)=O)=CC=C2)=O)CC1

Bacterial

Room temperature