PD-1/PD-L1-IN-19 [CAS 2156651-18-0]

PD-1/PD-L1-IN-19 (Example 22) is a small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction. PD-1/PD-L1-IN-19 blocks PD-1/PD-L1 with the IC50 of 62.3 nM. PD-1/PD-L1-IN-19 can be used for the research of cancers, infectious diseases and autoimmune diseases[1].

[2156651-18-0]

C32H29BrClN3O3

618.95

N#CC1=CC=CC(COC2=CC(OCC3=CC=CC(C4=CC=CC=C4)=C3Br)=C(C=C2CNCCNC(C)=O)Cl)=C1

PD-1/PD-L1

10 mM in DMSO

Room temperature