PD-1/PD-L1-IN-20 [CAS 2159138-01-7]

PD-1/PD-L1-IN-20 (Example 21) is a small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction. PD-1/PD-L1-IN-20 blocks PD-1/PD-L1 with the IC50 of 5.29 nM. PD-1/PD-L1-IN-20 can be used for the research of cancers, infectious diseases and autoimmune diseases[1].

[2159138-01-7]

C30H26BrClN2O3

577.9

N#CC1=CC=CC(COC2=CC(OCC3=CC=CC(C4=CC=CC=C4)=C3Br)=C(C=C2CNCCO)Cl)=C1

PD-1/PD-L1

10 mM in DMSO

Room temperature