PD-1/PD-L1-IN-34 [CAS 2924403-17-6]

PD-1/PD-L1-IN-34 (Compound (1S,2S) -A25) inhibits PD-1/PD-L1 interaction (IC50=0.029 μM), with a selected binding affinity with PD-L1 (KD=0.1554 μM) . PD-1/PD-L1-IN-34 inhibits tumor growth by activating the immune microenvironment[1].

[2924403-17-6]

C35H33ClN2O3

565.1

CC1=C([C@@H]2[C@@H](C3=CC(OCC4=CC=CC(C#N)=C4)=C(C=C3Cl)CNC(C)(C(O)=O)C)C2)C=CC=C1C5=CC=CC=C5

PD-1/PD-L1

10 mM in DMSO

Room temperature