PD-L1-IN-3 [CAS 2953044-29-4]

PD-L1-IN-3 (Compound 4a) is a compound that targets PD-1/PD-L1, the IC50 value and EC50 value is 4.97nM and 2.70 μM for inhibit PD-L1 and Jurkat T cells, respectively. PD-L1-IN-3 can bind PD-L1 dimer to prevent PD-1 binding to PD-L1, therefore blocking PD-1 signaling. PD-L1-IN-3 can be used for lung cancer and melanoma diseases research[1].

[2953044-29-4]

C19H16ClFN2OS

374.86

FC1=CC=C(C2=CSC(OCC3=CC=C(CN)C=C3)=C2C#N)C=C1.Cl

PD-1/PD-L1

99.69

DMSO : 125 mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture)

Room Temperature