PD-L1-IN-6

PD-L1-IN-6 (Compound 16) is an orally active inhibitor for PD-L1 expression in neutrophil by targeting STAT3 with KD of 90.5 nmol/L. PD-L1-IN-6 promotes neutrophil-mediated antifungal immunoresponse[1].

C21H24Cl2O6S

475.38

O=C1O[C@@H]2[C@@]3([C@@]4([C@](C)(CC[C@H]2[C@@H]1CS(=O)(C5=C(C=CC=C5Cl)Cl)=O)O4)CC[C@]3(O)C)[H]

PD-1/PD-L1; STAT

10 mM in DMSO

Room temperature