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PD-L1/Nampt-IN-1 [CAS 3054043-85-2]
PD-L1/Nampt-IN-1 [CAS 3054043-85-2]
SKU:QM-0013022
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Product Details
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Description
PD-L1/Nampt-IN-1 is an orally active inhibitor that simultaneously target PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase) with IC50s value of 63 nM and 582 nM. PD-L1/Nampt-IN-1 demonstrates cross-species affinity with comparable KD values for hPD-L1 (52.6 nM) and mPD-L1 (49.1 nM), respectively. PD-L1/Nampt-IN-1 effectively inhibits tumor growth by activating the tumor immune microenvironment. PD-L1/Nampt-IN-1 can be used for the study of melanoma[1].
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CAS Number
[3054043-85-2]
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Molecular Formula
C28H28N4O2
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Molecular Weight
452.55
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Smiles
COC1=C(C=CC(C2=C(C(C3=CC=CC=C3)=CC=C2)C)=N1)CNCCNC(C4=CN=CC=C4)=O
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Target
NAMPT; PD-1/PD-L1
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Shipping Conditions
Room temperature
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PD-L1/Nampt-IN-1 [CAS 3054043-85-2]
PD-L1/Nampt-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.