PDDHV [CAS 179469-40-0]

PDDHV is a calcium absorption inducer and may achieve 45Ca2+ influx by stimulating vanillic acid receptor VR1. PDDHV induces 45Ca2+ uptake (EC50: 70 nM) in rat dorsal root ganglion neurons (expressing native vanilloid receptors) and calcium mobilization (EC50: 125 nM) in VR1-transfected CHO cells. PDDHV also inhibits [3H]-resiniferatoxin (RTX) binding to the dorsal root ganglion membrane in rats[1].

[179469-40-0]

C49H72O11

837.09

O=C(OCC(C[C@]12O)=C[C@]([C@@](C3(C)C)([H])[C@@]3(OC(CCCCCCCCC)=O)[C@H](OC(CCCCCCCCC)=O)[C@H]4C)([H])[C@@]4(O)[C@]2([H])C=C(C)C1=O)CC5=CC=C(O)C(OC)=C5

Calcium Channel

10 mM in DMSO

Room temperature

H301-H312-H330-H410

P264-P270-P330-P405-P501