PDEδ autophagic degrader 1 [CAS 3054112-59-0]

PDEδ autophagic degrader 1 (compound 12c), an autophagosome-tethering compound (ATTEC) . is a potent PDEδ autophagic degrader. PDEδ autophagic degrader 1 reduces the PDEδ protein level through lysosome-mediated autophagy without affecting the PDEδ mRNA expression. PDEδ autophagic degrader 1 suppresses the growth in KRAS mutant pancreatic cancer cells[1].

[3054112-59-0]

C41H42Br2IN7O5

999.53

O=C(NCCCCCCNC(COC1=C(Br)C=C(/C=C2C(NC3=C\2C=C(I)C=C3)=O)C=C1Br)=O)CCCN4N=C(C)C5=C(C)N(C6=CC=C(C)C=C6)N=C5C4=O

ATTECs; Autophagy; Phosphodiesterase (PDE)

10 mM in DMSO

Room temperature