PDEδ/NAMPT IN-1 [CAS 2976498-55-0]
PDEδ/NAMPT IN-1 [CAS 2976498-55-0]
SKU:QM-0011059
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Product Details
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Description
PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) (KD=0.410 nM) and nicotinamide phosphoribosyl transferase (NAMPT) (IC50=2.21 nM) . PDEδ/NAMPT IN-1 blocks KRAS-related signal transduction and interferes with the synthesis of nicotinamide adenine dinucleotide (NAD+), inducing apoptosis in KRAS mutant pancreatic cancer cells. PDEδ/NAMPT IN-1 is promising for research of KRAS mutant pancreatic cancer[1].
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CAS Number
[2976498-55-0]
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Molecular Formula
C26H30N4O4S
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Molecular Weight
494.61
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Smiles
O=S(C1=CC=C(C=C1)NC(NCC2=CC=CN=C2)=O)(N(CC3=CC=C(C=C3)OC)C4CCCC4)=O
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Target
Apoptosis; NAMPT; Phosphodiesterase (PDE)
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Isoform
PDE6
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Shipping Conditions
Room temperature
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PDEδ/NAMPT IN-1 [CAS 2976498-55-0]
PDEδ/NAMPT IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.