PDE4-IN-18

PDE4-IN-18 (compound 1l) is a PDE4 inhibitor (IC50=1.55 μM) with anti-inflammatory activity. PDE4-IN-18 exerts anti-inflammatory effects by reducing excessive immune cell infiltration and intestinal membrane formation, as well as reducing the mRNA expression of pro-inflammatory cytokines (such as TNF-α and IL-6) in synovial tissue. PDE4-IN-18 can be used in the study of rheumatoid arthritis and psoriasis[1].

C24H19FN2O3S

434.48

O=C1C2=CC(F)=CC=C2C(CC=C)=C(C3=CC(NS(=O)(C4=CC=CC=C4)=O)=CC=C3)N1

Interleukin Related; Phosphodiesterase (PDE) ; TNF Receptor

PDE4

Room temperature