PDE4-IN-28

PDE4-IN-28 (Compound G1) is a PDE4D inhibitor (IC50: 29 nM) . PDE4-IN-28 inhibits the production of TNF-α and NO (IC50: 13.32 and 2.32 μM, respectively) . PDE4-IN-28 exhibits anti-inflammatory, antibacterial and analgesic effects in a rat pressure ulcer (PU) model and promotes HUVEC cell migration, thereby accelerating wound healing[1].

C28H27F2N9O6

623.57

O=C1N(C2=C(C(N1C)=O)N(CCC(NNC(C3=NN4C(C5=CC(OCC6CC6)=C(C=C5)OC(F)F)=CC=NC4=C3)=O)=O)C=N2)C

Bacterial; NO Synthase; Phosphodiesterase (PDE) ; TNF Receptor

PDE4

Room temperature