PDE4-IN-30

PDE4-IN-30 is a selective PDE4 inhibitor with an IC50 of 2.7 nM for PED4D2, targeting PDE4 through halogen bonding and metal coordination. PDE4-IN-30 exhibits at least 67-fold selectivity for other PDE subfamilies. PDE4-IN-30 can be used for the research of idiopathic pulmonary fibrosis[1].

C14H17BrN8O2

409.24

NC1=C(C(NCCCC(NO)=O)=NC2=C(C=NN12)C3=CN(N=C3)C)Br

Phosphodiesterase (PDE)

PDE10; PDE4; PDE5; PDE8

Room temperature