PDE4-IN-8 [CAS 2415085-45-7]

PDE4-IN-8 (Example 5) is a potent PDE4 inhibitor with an IC50 of 0.93 nM for PDE4B2.PDE4-IN-8 has little effect on IL13 (IC50=4.04 nM), IL4 (IC50=36.33 nM), IFNy (IC50=2394 nM) [1].

[2415085-45-7]

C18H22BNO4

327.18

CCCOC1=C(OC)C=CC(C2=CN=CC([C@]3([H])CB(OC3)O)=C2)=C1

Interleukin Related; Phosphodiesterase (PDE)

IL-13; IL-4; PDE4

10 mM in DMSO

Room temperature