PDE5-IN-10

PDE5-IN-10 (compound 4b) is a potent PDE5 inhibitor with an IC50 of 20 nM. PDE5-IN-10 improves in vitro microsomal stability (t1/2 = 44.6 min) as well as excellent efficacy in restoring long-term potentiation. PDE5-IN-10 can be used for Alzheimer’s disease (AD) research[1].

C21H20N4O2

360.41

N#CC1=CC(C2CC2)=C3N=CC(CO)=C(NCC4=CC=C(OC)N=C4)C3=C1

Phosphodiesterase (PDE)

PDE5

10 mM in DMSO

Room temperature