PDHK-IN-5

PDHK-IN-5 (Compound 19) is a potent inhibitor of PDHK with IC50s of 0.006 and 0.0329 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating agent targets for numerous diseases, including diabetes and cancers. PDHK-IN-5 has the potential for the research of cancer diseases[1].

C30H31N5O2

493.6

CC1=NC2=C(C3=CC=CC(C4CC4)=C3N2)C=C1C5=NN=C(O5)C(C(C)C)CC(NCC6=CC=CC=C6)=O

PDHK

10 mM in DMSO

Room temperature