PDHK1-IN-3

PDHK1-IN-3 (Compound 29) is a selective PDHK1 inhibitor with an IC50 of 0.028 μM against PDHK1 and an IC50 of 0.120 μM against PDHK2. PDHK1-IN-3 inhibits the activity of PDHK1 by forming a covalent bond with Lys299 in PDHK1. PDHK1-IN-3 can be used in the research of autoimmune diseases, inflammatory diseases, and cancer[1].

C21H17F2N3O4S

445.44

CCNC1=C2C(N(C3=CC=C(OC4=CC=CC(S(=O)(F)=O)=C4)C=C3)C(N2)=O)=CC(F)=C1

PDHK

Room temperature