PDIA1-IN-1

PDIA1-IN-1 is a protein disulfide isomerase 1 (PDIA1) inhibitor. PDIA1-IN-1 can inhibit NLRP3 inflammasome assembly and activity, with an IC50 value of 1 μM. PDIA1-IN-1 can reduce IL-1β secretion. PDIA1-IN-1 can be used for the researches of inflammation and neurological disease[1].

C29H35N3O7S

569.67

C#CCCNC([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1)=O)CC2=CC=C(C=C2)OS(=O)(C=C)=O)=O

Interleukin Related; PDI

IL-1

Room temperature