Pellotine [CAS 19622-05-0]

Pellotine is an alkaloid that can be isolated from Lophophora. Pellotine is the inverse agonist for 5-HT7 receptor with an EC50 of 291 nM. Pellotine exhibits good affinity to 5-HT1DR and 5-HT6R with Ki of 117 nM and 170 nM. Pellotine reduces intracellular cAMP levels, thereby reducing neuronal excitability and neurotransmitter release[1].

[19622-05-0]

C13H19NO3

237.29

COC1=C(OC)C(O)=C(C(C)N(C)CC2)C2=C1

5-HT Receptor

5-HT7 Receptor; mLAG-3; MUC2; MUC3

Room temperature