Penehyclidine [CAS 87827-02-9]

Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1][2].

[87827-02-9]

C20H29NO2

315.45

OC(COC1CN2CCC1CC2)(C3CCCC3)C4=CC=CC=C4

MAChR; NF-κB

MAChR1; mAChR3; NF-κB

10 mM in DMSO

Room temperature