Pentamidine [CAS 100-33-4]

Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

[100-33-4]

C19H24N4O2

340.42

N=C(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N

Antibiotic; Bacterial; Fungal; Parasite; Phosphatase

Leishmania; Trypanosoma

97.19

DMSO : 3.3 mg/mL (ultrasonic; warming; adjust pH to 6 with 1 M HCl; heat to 60°C)

4°C (Powder, protect from light)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335