Periplanetasin-4 [CAS 2206807-06-7]

Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana) . Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis[1][2].

[2206807-06-7]

C70H110N20O15S

1503.81

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CC=C(C=C2)O)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CS)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(NCC(N4[C@@H](CCC4)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

Apoptosis; Bacterial; Caspase; p38 MAPK; Reactive Oxygen Species (ROS)

Room temperature