PF-06380101-d8

PF-06380101-d8 (Aur0101-d8) is a deuterium labeled PF-06380101. PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue[1].

C39H54D8N6O6S

751.06

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C2=NC=CS2)CC3=CC=CC=C3)=O)OC)=O)OC)N(C([C@@](C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])([2H])NC(C(C)(C)N)=O)=O)C

ADC Payload; Microtubule/Tubulin

Auristatin

99.27

DMSO : 35 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C (Powder, sealed storage, away from moisture)

Blue Ice