PF-3166

PF-3166 is a PAD2 inhibitor (IC50=150 nM) that is competitive with Ca2+. TPF-3166 insignificantly inhibits PAD3 or PAD4 (80 μM) . PF-3166 also inhibits NH3 release (IC50=580 nM) .[1].

C43H42BrClN6O5S

870.25

O=C([C@@H]1N(CC2=CC=C3C(N([C@H](C4=CC=CC=C4Br)CC(NC5=CC(NS(=O)(C)=O)=CC=C5C)=O)C(C6=CC=CC(OC7=CC=C(Cl)C=C7)=C6)=N3)=C2)CCC1)NC

Protein Arginine Deiminase

Room temperature