PF-3644022 [CAS 1276121-88-0]

PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect[1].

[1276121-88-0]

C21H18N4OS

374.46

O=C1C2=C(NC[C@@H](C)N1)C3=C(C=CC4=NC(C5=CN=C(C)C=C5)=CC=C34)S2

MAPKAPK2 (MK2) ; p38 MAPK

10mM

99.65

DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 80°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H319, H413

H302, H319, H413