PF-3837 [CAS 2772910-13-9]

PF-3837 is an Mps1 kinase inhibitor with a Ki value of 0.33 nM and an IC50 value of 5.5 nM. PF-3837 interferes with the cell cycle checkpoint by inhibiting Mps1 catalytic activity, reducing genomic stability, thereby inducing cancer cell apoptosis (Apoptosis) . PF-3837 can be used in research on breast cancer[1].

[2772910-13-9]

C21H26N8O2

422.48

N#CC1=CNC2=NC(NC3=CC=C(N4CCOCC4)N=C3C)=NC(NC(C)(CO)C)=C12

Apoptosis; Mps1

Room temperature